Systematic Review of Colistimethate Sodium Dry Powder and Tobramycin Dry Powder Antibiotics for Pseudomonas Aeruginosa Lung Infection in Cystic Fibrosis
نویسندگان
چکیده
منابع مشابه
Systematic review of the dry powder inhalers colistimethate sodium and tobramycin in cystic fibrosis.
This systematic review evaluated evidence for two dry powder formulations, colistimethate sodium and tobramycin, for the treatment of chronic Pseudomonas aeruginosa in cystic fibrosis, as part of the UK national recommendation process for new technologies. Electronic bibliographic databases were searched in May 2012 (MEDLINE, MEDLINE in-Process, EMBASE, Cochrane Library databases, CINAHL, Web o...
متن کاملColistimethate sodium powder and tobramycin powder for inhalation for the treatment of chronic Pseudomonas aeruginosa lung infection in cystic fibrosis: systematic review and economic model.
BACKGROUND Cystic fibrosis (CF) is an inherited condition characterised by the abnormal transport of chloride ions across transporting epithelia. This leads to the production of thick sticky mucus in the lungs, pancreas, liver, intestine and reproductive tract, and an increase in the salt content in sweat. Among other problems, people with CF experience recurrent respiratory infections and have...
متن کاملCiprofloxacin dry powder inhaler in cystic fibrosis.
Correspondence to Professor J Stuart Elborn; [email protected] Inhaled antibiotics are the backbone of care for people with cystic fibrosis (CF) who have lung infection due to Pseudomonas aeruginosa. They have significantly contributed to the improved quality of life (QOL) and increased survival in people with this disease. The systematic application of antibiotic eradication therapy for new o...
متن کاملDevelopment and Investigation of Dry Powder Inhalers for Cystic Fibrosis
Cystic Fibrosis (CF) is the most common lethal monogenic disorder in Caucasians, estimated to affect one per 2500-4000 newborns. CF is caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) [1, 2]. CFTR acts mainly as a chloride channel and has other regulatory roles, including inhibition of sodium transport through the epithelial sodium channel, regulation o...
متن کاملEconomic Evaluation of Tobramycin Inhalation Powder for the Treatment of Chronic Pulmonary Pseudomonas aeruginosa Infection in Patients with Cystic Fibrosis
BACKGROUND Chronic lung infection with Pseudomonas aeruginosa occurs in approximately 50% of patients with cystic fibrosis (CF). This infection further compromises lung function, and significantly contributes to the increased healthcare costs. OBJECTIVES Inhaled tobramycin, used to manage P. aeruginosa infection in CF patients, is available as powder (tobramycin inhalation powder, TIP) and so...
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ژورنال
عنوان ژورنال: Value in Health
سال: 2013
ISSN: 1098-3015
DOI: 10.1016/j.jval.2013.08.257